*M.Rickert1, I.Papachristos1, M. Rauschmann1

Randomisierte Evaluation der knöchernen Durchbauung nach ventraler Fusion der Lendenwirbelsäule (ALIF) mit einem neuen osteoinduktiven Knochenersatzmaterial

Radiologisches Outcome nach 12 Monaten

1Orthopädische Universitätsklinik Friedrichsheim, Wirbelsäulenorthopädie, Frankfurt am Main, Deutschland

 Eur Spine J(2015) 24:2614-2707


Seifi M, Arayesh A, Shamloo N, Hamedi R.

Effect of nanocrystalline hydroxyapatite socket preservation on orthodontically induced inflammatory root resorption

Cell J. 2015 Winter;16(4):514-27. Epub 2015 Jan 13.


Boos A, Weigand A, Deschler G, Gerber T Arkudas A Kneser U, Horch RE, Beier JP

Autologous serum improves bone formation in a primary stable silica-embedded nanohydroxyapatite bone substitute in combination with mesenchymal stem cells and rhBMP-2 in the sheep model

International Journal of Nanomedicine 2014:9 5317–5339


Lorenz J, Kubesch A, Korzinskas T, Barbeck M, Landes C, Sader R, Kirkpatrick CJ, Ghanaati S.

TRAP-positive multinucleated giant cells are foreign body giant cells rather than osteoclasts: Results from a split-mouth study in humans

J Oral Implantol. 2014 Dec 9. [Epub ahead of print]


Wolf M, Wurm A, Heinemann F, Gerber T, Reichert C, Jäger A, Götz W.

The effect of patient age on bone formation using a fully synthetic nanocrystalline bone augmentation material in maxillary sinus grafting

Int J Oral Maxillofac Implants. 2014 Jul-Aug;29(4):976-83. doi: 10.11607/jomi.3525.


Reichert C, Wenghoefer M, Kutschera E, Götz W, Jäger A.

[Ridge preservation with synthetic nanocrystalline hydroxyapatite reduces the severity of gingival invaginations-a prospective clinical study]

[Article in German]

J Orofac Orthop. 2014 Jan;75(1):7-15. doi: 10.1007/s00056-013-0175-7. Epub 2014 Jan 19.


Konermann A, Staubwasser M, Dirk C, Keilig L, Bourauel C, Götz W, Jäger A, Reichert C.

Bone substitute material composition and morphology differentially modulate calcium and phosphate release through osteoclast-like cells

Int J Oral Maxillofac Surg. 2014 Apr;43(4):514-21. doi: 10.1016/j.ijom.2013.10.017. Epub 2013 Nov 20.




Ghanaati S, Barbeck M, Lorenz J, Stuebinger S, Seitz O, Landes C, Kovács AF, Kirkpatrick CJ, Sader RA

Synthetic bone substitute material comparable with xenogeneic material for bone tissue regeneration in oral cancer patients: First and preliminary histological, histomorphometrical and clinical results

Annals of Maxillofacial Surgery / July-December 2013 / Volume 3 / Issue 2


Möller B, Acil Y, Birkenfeld F, Behrens E, Terheyden H, Wiltfang J

Highly porous hydroxyapatite with and without local harvested bone in sinus floor augmentation: a histometric study in pigs

Clin. Oral Impl. Res. 2014 Jul;25(7):871-8. doi: 10.1111/clr.12161. Epub 2013 Apr 9.


Reichert C, Götz W, Reimann S, Keilig L, Hagner M, Bourauelc, Jäger A

Resorption behavior of a nanostructured bone substitute: in vitro investigation and clinical application

J Orofac Orthop. 2013 Mar;74(2):165-74. doi: 10.1007/s00056-012-0136-6. Epub 2013 Mar 8.


Gems M, Müller W, Porrmann T, Mader T, Göbel P

Erste Erfahrungen mit dem synthetischen, resorbierbaren Knochenersatzmaterial NanoBone®bei juvenilen Knochenzysten am Humerus

Poster, 32. Jahrestagung der Sektion Kindertraumatologie in der Gesellschaft für Unfallchirurgie e.V., Frankfurt / Main 2013


Ghanaati S, Lorenz J, Obreja K, Choukroun J, Landes C, Sader R.

Nanocrystaline hydroxyapatatite-based material contributes to implant stability already after three month: A Clinical and radiological 3 year follow- up investigation

J Oral Implantol. 2014 Feb;40(1):103-9. doi: 10.1563/AAID-JOI-D-13-00232. Epub 2013 Sep 17.


Behnia H, Khojasteh A, Kiani MT, Khoshzaban A, Mashhadi Abbas F, Bashtar M, Dashti SG.

Bone regeneration with a combination of nanocrystalline hydroxyapatite silica gel, platelet-rich growth factor, and mesenchymal stem cells: a histologic study in rabbit calvaria.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Feb;115(2):e7-15. doi: 10.1016/j.oooo.2011.09.034. Epub 2012 May 30.


Gerber T, Ganz C, Xu W, Maier F, Frerich B, Lenz S

Bone Grafting Putty – Animal Experiments and Clinical Applications

Key Engineering Materials Vols. 529-530 (2013) pp 285-290


Punke C, Goetz W, Just T, Pau HW

Mastoid obliteration with a highly porous bone grafting material in combination with cartilage

Laryngorhinootologie. 2012 Sep;91(9):566-70. Epub 2012 Jul 30. German.


Harms C, Helms K, Taschner T, Stratos I, Ignatius A, Gerber T, Lenz S, Rammelt S, Vollmar B, MittlmeierT

Osteogenic capacity of nanocrystalline bone cement in a weight-bearing defect at the ovine tibial metaphysis.

Int J Nanomedicine. 2012;7:2883-9. Epub 2012 Jun 15.



Kutschera E, Wenghoefer M, Keilig L, Jäger A, Reichert C

Ridge preservation with NanoBone®– A new approach to avoid gingival clefts following extraction treatment?

Poster, 88th EOS Congress 2012, Santiago de Compostela




Punke Ch, Zehlicke T, Just T, Holzhüter G, Gerber T, Pau HW

Matrix change of bone grafting substitute after implantation into guinea pig bullae

Folia Morphol (Warsz). 2012 May;71(2):109-14.



Ghanaati S, Barbeck M, Willerhausen I, Thimm B, Stuebinger S, Korzinskas T, Obreja K, Landes C, Kirkpatrick CJ, Sader RA

Nanocrystalline Hydroxyapatite Bone Substitute Leads to Sufficient Bone Tissue Formation, Already after 3 Month: Histological and Histomorphometrical Analysis 3 and 6 Months following Human Sinus Cavity Augmentation

Clin Implant Dent Relat Res. 2012 Jan 17.doi:10.1111/j. 1708-8208.2011.00433.x.



Gholami G, Najafi B, Mashhadiabbas F, Goetz W, Najafi S

Clinical, histologic and histomorphometric evaluation of socket preservation using a synthetic nanocrystalline hydroxyapatite in comparison with a bovine xenograft: a randomized clinical trial

Clin Oral Implants Res. 2011 Aug 18.doi:10.1111/j.1600-0501.2011.02288.x.[Epub ahead of print]



Gerber T, Lenz S, Holzhüter G, Götz W, Helms K, Harms C, Mittlmeier T

Nanostructured Bone Grafting Substitutes - A Pathway to Osteoinductivity

Key Engineering Materials Vols. 493-494 2012;pp 147-152



Ganz C, Xu W, Holzhüter G, Götz W, Vollmar B, Gerber T

Comparison of bone substitutes in a tibia defect model in Wistar-rats

Key Engineering Materials Vols. 493-494 2012;pp 732-738



Keuer H, Ganz C, Xu W, Frerich B, Gerber T

Bioactive Coating on Porous Materials with an Interconnected Pore System to Improve Osseointegration

Key Engineering Materials Vols. 493-494 2012;pp 499-503



Adam M, Ganz C, Xu W, Sarajian H R, Frerich B, Gerber T

How to Enhance Osseointegration - Roughness, Hydrophilicity or Bioactive Coating?

Key Engineering Materials Vols. 493-494 2012;pp 467-472 



Xu W, Ganz C, Weber U, Adam M, Holzhüter G, Wolter D, Frerich B, Vollmar B, Gerber T

Evaluation of injectable silica-embedded nanohydroxyapatite bone substitute in a rat tibia defect model

Int J Nanomedicine. 2011;6:1543-52



Kressin S

Die Behandlung von mehrwandigen Knochendefekten

Implantologie Journal. 2011;4:50-54



Klein MO, Kämmerer PW, Scholz T, Moergel M, Kirchmaier CM, Al-Nawas B

Modulation of platelet activation and initial cytokine release by alloplastic bone substitute materials

Clin Oral Implants Res. 2010 Mar;21(3):336-45



Reichert C, Wenghöfer M, Götz W, Jäger A

Pilot study on orthodontic space closure after guided bone regeneration

J Orofac Orthop 2011;72:45-50


Kirchhoff M, Lenz S, Henkel KO, Frerich B, Holzhüter G, Radefeldt S, Gerber T

Lateral augmentation of the mandible in minipigs with a synthetic nanostructured hydroxyapatite block

J Biomed Mater Res B Appl Biomater. 2011 Feb;96(2):342-50



Liu Q, Douglas T, Zamponi C, Becker ST, Sherry E, Sivananthan S, Warnke F, Wiltfang J, Warnke PH

Comparison of in vitro biocompatibility of NanoBone® and BIO OSS® for human osteoblasts

Clin Oral Implants Res.2011 Nov;22(11):1259-64


Kruse A, Jung RE, Nicholls F, Zwahlen RA, Hämmerle CHF, Weber FE

Bone regeneration in the presence of a synthetic hydroxyapatite/silica oxide-based and a xenogenic hydroxyapatite-based bone substitute material

Clin. Oral Impl. Res. 22, 2011; 506-511


Götz W, Lenz S, Reichert C, Kenkel KO, Bienengräber V, Pernicka L, Gundlach KKH, Gredes T, Gerber T, Gedrange T, Heinemann F

A preliminary study in osteoinduction by a nano-crystalline hydroxyapatite in the mini pig

Folia Histochem Cytobiol.2010:48(4):589(589-596)



Ghanaati S, Orth C, Barbeck M, Willershausen I, Thimm BW, Booms P, Stübinger S, Landes C, Sader RA, Kirkpatrick CJ

Histological and histomorphometrical analysis of a silica matrix embedded nanocrystalline hydroxyapatite bone substitute using the subcutaneous implantation model in Wistar rats.

Biomed Mater. 2010 May 11;5(3):035005.[Epub ahead of print]







Klein MO, Gotz H, Duschner H, Wagner W

Bony integration of an alloplastic bone substitute material (NanoBone®) after maxillary sinus augmentation

Z Zahnärztl Impl 2009; 25(4): 20-28


Mertens C, Steveling H

Use of Synthetic Bone Blocks as an Alternative to Autologous Bone Blocks Grafts

Implants, International Magazine of Oral Implantology 2009; 4:30-32



Xu W, Holzhüter G, Sorg H, Wolter D, Lenz S, Gerber T, Vollmar B

Early matrix change of a nanostructured bone grafting substitute in the rat.

J Biomed Mater Res B Appl Biomater. 2009 Nov; 91(2): 692-9





Canullo L, Vozza I, Caricato F, Dellavia C

Maxillary sinus floor augmentation using a nano-crystalline hydroxyapatite silica gel

A prospective study - Histological results after 3 months of healing

implants, International Magazine of Oral implantology 2009; 2:24-27


Stübinger S, Ghanaati S, Orth C, Hilbig U, Saldamli B, Bisterfeld S, Kirkpatrick CJ, Sader RA

Maxillary sinus grafting with a nano-structured biomaterial: preliminary clinical and histological results.

EUR Surg Res. 2009; 42(3): 143-9. Epub 2009 Jan.29.


Abshagen K, Schrodi I, Gerber T, Vollmar B

In vivo analysis of biocompatibility and vascularization of the synthetic bone grafting substitute NanoBone®

J Biomed Mater Res A 2008 in press


Kruse A, Jung RE, Nicholls F, Zwahlen RA, Hämmerle CHF, Grätz KW, Weber FE

Comparison of synthetic HA/SiO2 matrix and bovine derived HA

EAO 17th International Meeting, Poster 243


Lenz S, Kirchhoff M, Gerber T

Enhanced osseointegration of implants with a nanostructured bioactive coating

EAO 17th International Meeting, Poster 391


Götz W, Gerber T, Michel B, Lossdörfer S, Henkel KO, Heinemann F

Immunohistochemical characterization of nanocrystalline hydroxyapatite silica gel (NanoBone®) osteogenesis: A study on biopsies from human jaws

Clin Oral Impl Res 2008; 19;1016-1026

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