info@artoss.com

NanoBone®
Mode of action

granule-based products


Macroworld

NanoBone®
Mode of action

granule-based products

1

Substrate

Hydrogel on a polymer silica base

2

Granulate

Nanostructured hydroxyapatite (HA) in a highly porous silica gel matrix

3

Start Stage I:

Neovascularisation and decomposition of the substrate advance from the edge of the defect inwards as a front

The molecular silica released by decomposition of the substrate speeds up vascularisation of the defect and thus promotes wound healing as a whole.

Microworld

Stage 1

  • Decomposition of the substrate
  • Neovascularisation of the defect
  • The silica gel matrix of the granulate is replaced by a matrix consisting of autologous proteins

Nano world

1

The silica gel matrix incorporates the individual HA crystallites. It is highly porous and is permeable to autologous proteins.

2

HA crystallites are morphologically identical to biological HA in the bone.

3

An organical matrix made from autologous proteins replaces the silica gel matrix due to the high affinity of the proteins to the surface of HA crystallites.

MATRIX CHANGE

Nano world

1

NanoBone® after stage 1

Organic matrix

  • BMPs
  • Osteocalcin
  • Osteopontin
  • Glycoproteins

HA crystallites in NanoBone® and bones have an identical structure.

A

random

regular

B

2

Natural bone

Organic matrix

  • Collagen
  • BMPs
  • Osteocalcin
  • Osteopontin
  • Glycoproteins

1

NanoBone® after stage 1

Organic matrix

  • BMPs
  • Osteocalcin
  • Osteopontin
  • Glycoproteins

HA crystallites in NanoBone® and bones have an identical structure.

A

random


2

Natural bone

Organic matrix

  • Collagen
  • BMPs
  • Osteocalcin
  • Osteopontin
  • Glycoproteins

HA crystallites in NanoBone® and bones have an identical structure.

B

regular

Stage 2

  • Decomposition of the granulate by osteoclasts
  • The granulate is permeated by tissue paths
  • Formation of woven bone around and in the granulate

Stage 3

  • Remodelling
  • The woven bone is replaced by lamellar bone of a higher quality
  • Remaining organic material is decomposed by osteoclasts

Cellular processes

Model of a rabbit femur with NanoBone® SBX Putty in the defect 4 weeks post-surgically.
Haematoxylin-eosin (HE) – stain

Woven bone in the granulate

Border of a granule

Severely vascularised bone marrow

Tissue path through the granulate

Woven bone