NanoBone®
Mode of action
granule-based products
Macro world
NanoBone®
Mode of action
granule-based products
3
Start Stage I:
Neovascularisation and decomposition of the carrier advance from the edge of the defect inwards as a front
The molecular silica released by decomposition of the carrier speeds up vascularisation of the defect and thus promotes wound healing as a whole.
Micro world
Stage 1
- Decomposition of the carrier
- Neovascularisation of the defect
- The silica gel matrix of the granulate is replaced by a matrix consisting of autologous proteins
Nano world
1
The silica gel matrix incorporates the individual HA crystallites. It is highly porous and is permeable to autologous proteins.
2
HA crystallites are morphologically identical to biological HA in the bone.
3
An organical matrix made from autologous proteins replaces the silica gel matrix due to the high affinity of the proteins to the surface of HA crystallites.
MATRIX CHANGE
Nano world
1
NanoBone® after stage 1
Organic matrix
- BMPs
- Osteocalcin
- Osteopontin
- Glycoproteins
HA crystallites in NanoBone® and bones have an identical structure.
A
random
regular
B
2
Natural bone
Organic matrix
- Collagen
- BMPs
- Osteocalcin
- Osteopontin
- Glycoproteins
1
NanoBone® after stage 1
Organic matrix
- BMPs
- Osteocalcin
- Osteopontin
- Glycoproteins
HA crystallites in NanoBone® and bones have an identical structure.
A
random
2
Natural bone
Organic matrix
- Collagen
- BMPs
- Osteocalcin
- Osteopontin
- Glycoproteins
HA crystallites in NanoBone® and bones have an identical structure.
B
regular
Stage 2
- Decomposition of the granulate by osteoclasts
- The granulate is permeated by tissue paths
- Formation of woven bone around and in the granulate
Stage 3
- Remodelling
- The woven bone is replaced by lamellar bone of a higher quality
- Remaining organic material is decomposed by osteoclasts
Cellular processes
Rabbit femur with NanoBone® SBX Putty in the defect 4 weeks post-surgically.
Haematoxylin-eosin (HE) – stain
Woven bone in the granulate
Border of a granule
Severely vascularised bone marrow
Tissue path through the granulate
Woven bone